publications

Recent Publications.

Bernstein, H.S., and Coughlin, S.R. (1997) Pombe Cdc5-related protein:  A putative human transcription factor implicated in mitogen-activated signaling.  J Biol Chem  272(9):5833-5837.

Bernstein, H.S., and Coughlin, S.R. (1998) A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem  273(8):4666-4671.

Bristow, J.D., and Bernstein, H.S. (1998) Counseling families with chromosome 22q11 deletions: The catch in CATCH-22. J Am Coll Cardiol 32(2):499-501.

Bernstein, H.S.  (2000) Cell cycle regulation and myocardial regeneration.  Congress Report from the 64th Annual Meetings of the Japanese Circulation Society [Online.] http://www.j-circ.or.jp/english/sessions/reports/64th-ss/bernstein.htm [22 April 2008, last date accessed].

Lei, X.-H., Shen, X., Xu, X.-Q., and Bernstein, H.S.  (2000) Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein.  J Cell Sci 113:4523-4531.

Hlaing, M., Shen, X., Dazin, P., and Bernstein, H.S. (2002) The hypertrophic response in C2C12 myoblasts recruits the G1 cell cycle machinery. J Biol Chem 277:23794-23799.

Shen, X., Collier, J.M., Hlaing, M., Zhang, L., Delshad, E.H., Bristow, J., and Bernstein, H.S. (2003) Genome-wide examination of myoblast cell cycle withdrawal during differentiation.  Devel Dynam 226:128-138.

Liu, L., Gräub, R., Hlaing, M., Epting, C.L., Turck, C.W., Zhang, L., Xu, X.-Q., and Bernstein, H.S.  (2003) Distinct domains of human Cdc5 direct its nuclear import and association with the spliceosome. Cell Biochem Biophys 39:119-131.

Hlaing, M., Spitz, P., Padmanabhan, K., Cabezas, B., Barker, C.S., and Bernstein, H.S. (2004) E2F-1 regulates the expression of a subset of target genes during skeletal myoblast hypertrophy. J Biol Chem 279:43625-43633.

Epting, C.L., López, J.E., Shen, X., Liu, L., Bristow, J., and Bernstein, H.S. (2004) Stem cell antigen-1 is necessary for cell cycle withdrawal and myoblast differentiation in C2C12 cells. J Cell Sci 117:6185-6195.

Hansel, D.E., Dhara, S., Huang, R.C., Ashfaq, R., Diesel, M., Shimada, Y., Bernstein, H.S., Harmon, J., Brock, M., Forastiere, A., Washington, M.K., Maitra, A., and Montgomery, E. (2005) CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a cancer progression marker and potential novel drug target. Am J Surg Path 29:390-399.

Williams, S.D., Zhu, H., Zhang, L., and Bernstein, H.S. (2006) Adenoviral delivery of human CDC5 promotes G2/M progression and cell division in neonatal ventricular cardiomyocytes.  Gene Therapy 13:837-843.

Epting, C.L.*, López, J.E.*, Pedersen, A., Brown, C., Spitz, P., Ursell, P.C., and Bernstein, H.S. (2008) Stem cell antigen-1 regulates the tempo of muscle repair through effects on proliferation of a7 integrin-expressing myoblasts.  Exp Cell Res 314:1125-1135. *These authors contributed equally and are listed alphabetically.

Ivey, K.N., Muth, A., Arnold, J., King, F.W., Yeh, R.-F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., and Srivastava, D. (2008) MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.  Cell Stem Cell 2:1-11.

Gräub, R., Lancero, H., Pedersen, A., Chu, M., Padmanabhan, K., Xu, X.-Q., Spitz, P., Chalkley, R., Burlingame, A.L., Stokoe, D. and Bernstein, H.S. (2008) Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. Cell Cycle 7:1795-1803.

Epting, C.L., King, F.W., Pedersen, A., Zaman, J. and Bernstein, H.S. (2008) Stem cell antigen-1 localizes to lipid microdomains and associates with Insulin Degrading Enzyme in skeletal myoblasts. J Cell Physiol 217:250-260.

Recent Presentations.

Chu, M., Xu, X., Lei, X., Turck, C.W., and Bernstein, H.S. (1999) A transcriptional regulator of G2/M responds to mitogen-activated signals through phosphorylation by protein kinase C. Circ 100:I-690 (American Heart Association Scientific Sessions).

Shen, X., Delshad, E., and Bernstein, H.S. (2000) Myoblastic C2C12 cells provide a model for studying cell cycle events limiting myocardial regeneration. Mol Biol Cell 11:14a (American Society for Cell Biology Annual Meeting).

Liu, L., Xu, X., and Bernstein, H.S. (2001) Human Cdc5 associates with the spliceosome and participates in pre-mRNA splicing via specific domains. Ped Res 49:53A (Society for Pediatric Research Annual Meeting).

Gräub, R., Padmanabhan, K., Stokoe, D., Chalkley, R., Burlingame, A., and Bernstein, H.S. (2003) The role of phosphorylation in human CDC5 function. FASEB J 17:A976 (American Society for Biochemistry and Molecular Biology Annual Meeting).

Epting, C.L., Shen, X., Liu, L., Zhang, L., Bristow, J., and Bernstein, H.S. (2003) GPI-anchored proteins regulate cell cycle withdrawal and myoblast fusion during differentiation. Ped Res 53:36A (Society for Pediatric Research Annual Meeting).

Hlaing, M., Spitz, P., Padmanabhan, K., Cabezas, B., Barker, C., and Bernstein, H.S. (2004) E2F-1 regulates a subset of target genes during cell growth without division. FASEB J 18:C97 (International Union for Biochemistry and Molecular Biology/American Society for Biochemistry and Molecular Biology Annual Meeting).

Epting, C.L., López, J.E., and Bernstein, H.S. (2005) Stem cell antigen-1 may identify a self-renewing population of myoblasts. Ped Res 57:91 (Society for Pediatric Research Annual Meeting).

López, J.E., Brown, C., Spitz, P., and Bernstein, H.S. (2005) Stem cell antigen-1 regulate muscle regeneration in vivo. Ped Res 57:1981(Society for Pediatric Research Annual Meeting).

Epting, C.L., King, F.W., López, J.E., and Bernstein, H.S. (2006) Stem cell antigen-1 signals through lipid microdomains and associated proteins in differentiating myoblasts. Ped Res E-PAS2006:59:3732.8 (Society for Pediatric Research Annual Meeting).

King, F.W., Nicholas, C., Leavitt, A., Reijo Pera, R., and Bernstein, H.S. (2006) Human embryonic stem cells expressing green fluorescent protein differentiate into mature cardiomyocytes. Ped Res E-PAS2006:59:5150.8 (Society for Pediatric Research Annual Meeting).

Bernstein, H.S. (2006) Symposium Lecture:  Recent History of Secondary Cardiac Myogenesis.  Ped Res E-PAS2006:59 (Society for Pediatric Research Annual Meeting).

Bernstein, H.S. and King, F.W. (2007) A novel approach to developmental synchronization of human embryonic stem cells. (Keystone Symposium: Integrative Basis of Cardiovascular Disease).

Ivey, K., Arnold, J., King, F.W., Bernstein, H.S., and Srivastava, D. (2007) MicroRNAs regulate cardiomyocyte differentiation from embryonic stem cells. (Keystone Symposium: Molecular Pathways in Cardiac Development and Disease).

Feraco, A., Shah, A., Harmon, C., Fineman, J., Tacy, T., and Bernstein, H.S. (2008) Identification of biomarkers of heart failure in single ventricle physiology. J Invest Med 56:37 (Western Society for Pediatric Research).

King, F.W. and Bernstein, H.S. (2008) CD133+ subpopulations of pluripotent human embryonic stem cells differentiate into neuroectoderm. FASEB J 22(suppl):576.1 (FASEB Experimental Biology 2008: American Society for Biochemistry and Molecular Biology).

Bernstein, H.S. (2008) Symposium lecture: Embryonic stem cell-based therapies for the injured heart. (American Heart Association: Scientific Basis of Heart Failure in Children).

Shah, A., Feraco, A., Harmon, C., Fineman, J., Tacy, T. and Bernstein, H.S. (2008) Establishing reference values for potential biomarkers of heart failure in children with single ventricle physiology. (American Heart Association: Scientific Basis of Heart Failure in Children).

King, F.W., Ritner, C., Pedersen, A., Leavitt, A.D. and Bernstein, H.S. (2008) Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures. (American Heart Association: Scientific Basis of Heart Failure in Children).

King, F.W., Wong, S., Ritner, C., Ding, C., Olgin, J. and Bernstein, H.S. (2008) An a-myosin heavy chain reporter cell line identifies human embryonic stem cell-derived myocardial precursors. (American Heart Association: Scientific Basis of Heart Failure in Children).

Gaur, M., Pedersen, A., Bernstein, H.S. and Yeghiazarians, Y. (2008) A small molecule inhibitor of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. (American Heart Association: Scientific Basis of Heart Failure in Children).